Global health review

MSF outreach workers test people for kala azar, Fulbaria, Mymensingh district, Bangladesh. Caption
MSF outreach workers test people for kala azar, Fulbaria, Mymensingh district, Bangladesh.

A weekly round-up of all the latest global health research from MSF projects and beyond

29 May 2026

Missed MSF Scientific Days 2026? The Royal Society of Tropical Medicine and Hygiene has published a blog reflecting on the event's key themes and discussions, describing it as "a timely reminder of how scientific evidence, when created and shared with integrity, can directly catalyse positive change in global health". Stay tuned to catch up on recordings and other MSF Scientific Days content on the MSF Science Portal.

 

This week, in Archives of Disease in Childhood, MSF and Epicentre co-contributed to a systematic review and meta-analysis comparing intravenous and oral rehydration strategies in children with severe malnutrition and severe dehydration. The authors found no clear difference in mortality between the two approaches, although intravenous rehydration was associated with fewer adverse events.

 

A global systematic review and meta-analysis with MSF contribution in The Pediatric Infectious Disease Journalfound that newer all-oral regimens for drug-resistant tuberculosis in children and adolescents are both effective and generally well tolerated.

 

In The Pan African Medical Journal, a study from Chad's N'Djamena North District reported that self-medication is common among pregnant women, with both health system barriers and behavioural factors contributing to the practice and underscoring the need for improved prenatal education.

 

Finally, MSF contributed to a perspective in Nature Medicine highlighting how limited access to quality diagnostic tests continues to hinder health outcomes and resilience to disease outbreaks across Africa. The authors call for context-specific health system strengthening measures to support greater self-reliance in health security and progress towards universal health coverage across the region.

 

Best regards,

 

Clara von Kaehne, Rosie Wharton, Lillian Matthes, and Holly Baker with MSF-authored article assistance from Alys Barton and Amelia Zhao.    

 

All MSF-authored publications can be found on the MSF Science Portal, as well as recordings, abstracts and posters from the MSF Scientific Days 2025 conference.

 

 

Climate change and planetary health

PLOS Neglected Tropical Diseases • Article: Climate change induced complex shifts in snake distributions expose people to snakebite and threaten biodiversity

Global Public Health • Article: Health system response to climate-related shocks in a lower-middle-income country setting: A comparative study of floods and droughts in Pakistan

BMC Health Services Research • Article: Healthcare system preparedness as a mediating factor in climate-driven tuberculosis outcomes: an ecological study
 

Conflict, migration and health

The Lancet Obstetrics, Gynaecology & Women's Health • Article: Association of armed conflict with extreme preterm birth and pre-eclampsia and eclampsia in Ukraine, 2022–24: a repeated cross-sectional national surveillance study

The BMJ • Opinion: Fear as policy: the health harms of immigration enforcement

The Lancet • Series***MENTIONS MSF***: John Hopkins Center for Humanitarian Health - LancetCommission on health, conflict, and forced displacement: health in a world of crises and impunity

The Lancet • Series: A much-needed reboot for international solidarity

The Lancet • Series: Transforming the humanitarian system

The Lancet • Series: Transforming the humanitarian system: our role to confront embedded inequities

The Lancet • Series: Making mutual aid the architecture of humanitarian response

The Lancet • Series***MENTIONS MSF***: Paul B Spiegel: pioneer in humanitarian health

BMC Health Services Research • Article: Quality health services and health research tailored for sexual and gender minority forced migrants: perspectives of migrants with lived experience and health service providers

Conflict and Health • Article: From HIV testing to ART initiation under fire: joinpoint regression analysis of regional disparities during the full-scale war against Ukraine

Conflict and Health • Article: Postoperative care in conflict-affected northwest Syria: a mixed-methods study assessing the perspectives of patients, health workers, and non-governmental organizations
 

Global health

The Lancet Global Health • Article: Cost of health systems strengthening for small and sick newborn care in four sub-Saharan African countries implemented with NEST360: incremental cost analyses

BMJ Global Health • Analysis: Demanding solidarity, not salvation: sex work and global health

PLOS Neglected Tropical Diseases • Article: Estimating the potential impact of global research on neglected tropical diseases on population-level indicators of health access, sanitation, and research capacity

BMC Health Services Research • Article: Rural physician deployment programs in five Southeast Asian countries: a policy and narrative review

BMC Health Services Research • Article: Women’s empowerment and barriers to healthcare access in Burkina Faso: an ordinal logistic regression analysis of the 2021 DHS

Nature Medicine • Perspectives***MSF AUTHOR***: The future of diagnostics in Africa
 

HIV

The Lancet eBioMedicine • Article: HIV-1 virome profiling using HIV-PULSE to guide therapeutic and curative interventions
The Lancet Regional Health Southeast Asia • Article: Virologic outcomes on Dolutegravir-based therapy among children and adolescents living with HIV in Thailand: findings from a national registry database

The Lancet Regional Health Africa • Article: Incidence rates of non-Hodgkin lymphoma subtypes among Black Africans with and without HIV in South Africa: a national registry-based study

The Lancet Infectious Diseases • Article: Global and regional molecular epidemiology of HIV-1 during 1990–2024: systematic review, global survey, and analysis of prevalence

JAMA • Article: Geospatial Access to CAR-T Clinical Trials for Non-Hodgkin Lymphoma for Persons With HIV

JAMA • Article: Homelessness and HIV Treatment Among Men Who Have Sex With Men Across US Funding Contexts

PLOS Medicine • Perspectives: U = U for all: Advancing equity in HIV prevention

Transactions of the Royal Sociaty of Tropical Medicine & Hygiene • Article: Long-acting antiretroviral injections: perspectives of people living with HIV in three Middle East countries

 

Infectious diseases

Global Public Health • Comment: Beyond the ‘End of AIDS’: What comes after 2030?

Tropical Medicine & International Health • Review: Comparative Impact of Active Versus Passive Surveillance on Hepatitis C Virus Testing Uptake, Diagnosis and Linkage to Care in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis

PLOS Neglected Tropical Diseases • Article: Characterization of the first complete genome sequence of yellow fever virus (YFV) in Sierra Leone: Implications for public health
 

Malaria

The Lancet Microbe • Article: Artemether-lumefantrine for the treatment of Plasmodium falciparum malaria in Laos: a therapeutic efficacy study coupled with genomic acid and in vitro phenotypic analyses

The Lancet Microbe • Article: Assessing the effect of parasite antigen genetic diversity on performance of Plasmodium vivax serological exposure markers for malaria: a multicentre observational diagnostic accuracy study

International Union Against Tuberculosis and Lung Disease • Article: Compliance with intermittent preventive malaria treatment in pregnancy at a tertiary hospital in Sierra Leone

International Union Against Tuberculosis and Lung Disease • Article: Mapping Malaria Hotspots through Spatial and Spatio-Temporal Analysis in Sierra Leone, 2021-2024

International Union Against Tuberculosis and Lung Disease • Article: Parenteral artesunate compliance and hospital outcomes in children under-five with suspected severe malaria in Sierra Leone

Malaria Journal • Review: Efficacy of artemether-lumefantrine for uncomplicated plasmodium falciparum malaria treatment in mozambique: a systematic review and meta-analysis

Malaria Journal • Case Study: Determinants of time to malaria treatment-seeking behaviour among caregivers of children under five in Uganda: a case study of Apac district

Malaria Journal • Article: Impact of proactive community case management of malaria on malaria prevalence in Bankass, Mali: a cluster-randomised controlled trial

Malaria Journal • Review: Plasmodium falciparum antimalarial resistance in Angola: a systemic review

Malaria Journal • Article: Prevalence and associated factors of microscopy-confirmed malaria among the general population in Ethiopia: a systematic review and meta-analysis

 

Maternal and child health

PLOS Medicine • Perspectives: Novel symptoms associated with eclampsia could improve detection and save lives

Archives of Disease in Childhood • Article***MSF AUTHOR***: Intravenous rehydration in children with severe malnutrition and severe dehydration: a systematic review and meta-analysis

The Pediatric Infectious Disease Journal • Article***MSF AUTHOR***: Effectiveness and Safety of Contemporary Drug Regimens for Multidrug- and Extensively Drug-resistant Tuberculosis in Children and Adolescents: A Global Systematic Review and Meta-analysis

The Pan African Medical Journal • Article***MSF AUTHOR***: Prevalence and associated factors of self-medication among pregnant women in N'Djamena North District, Chad
 

Mental health

The Lancet • Article: Updated trends in the global prevalence and burden of mental disorders, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023

BMC Health Services Research • Article: Passive-avoidant leadership and psychological distress among Iranian nurses: the mediating role of work–to-family conflict
 

Neglected tropical diseases

BMJ Global Health • Analysis: Decolonising Neglected Tropical Diseases research in Africa: insights, challenges and promising practices

Transactions of the Royal Sociaty of Tropical Medicine & Hygiene • Article: Molecular detection of Coxiella burnetii in ticks from livestock in Kashmir: first evidence and molecular insights

PLOS Neglected Tropical Diseases • Article: A multicenter hospital-based analysis of cystic Echinococcosis in Afghanistan: Filling a National data gap

PLOS Neglected Tropical Diseases • Review: Zoonotic leishmaniasis in China: Current status and challenges to elimination

PLOS Neglected Tropical Diseases • Article: Approaches to quantifying acceptability of pharmaceutical interventions for neglected tropical diseases: A scoping review

PLOS Neglected Tropical Diseases • Article: How rash and eschar came to clinical attention in scrub typhus and Japanese spotted fever

PLOS Neglected Tropical Diseases • Article: Parasite exosomes-derived circulating sja-miR-61 and sja-miR-7-5p as Novel biomarkers for the detection of Schistosoma japonicum infection using TagMan real-time PCR

PLOS Neglected Tropical Diseases • Article: Spatiotemporal trends of neglected tropical disease hospitalizations in Ecuador over 25-years from 2000 to 2024
 

Non-communicable diseases

The Lancet eClinicalMedicine • Article: Adverse childhood experiences and risk of non-mental medical diseases in adulthood: an umbrella review

The Lancet Regional Health Africa • Article: Prevalence of kidney dysfunction and impact on one-year outcomes in patients with chronic heart failure in an African tertiary health center: a longitudinal study

The Lancet Regional Health Southeast Asia • Article: Self-management education and support for type 2 diabetes in Thailand: a cluster randomized trial (2019–2021)

The Lancet Regional Health Africa • Article: Epidemiology of visual impairment and blindness in Africa: a systematic review and Bayesian meta-analysis

BMJ Global Health • Article: A new model for cervical cancer screening in Cambodian garment workers

Global Public Health • Article: Exploratory cross-sectional study of migration, BMI and blood pressure in rural and urban Peruvian indigenous women
 

Outbreaks

The BMJ • News: Ebola outbreak: 139 dead as WHO warns of “scale and speed” of spread in central Africa

The BMJ • News: Disease outbreaks such as Ebola and hantavirus are more frequent and deadly as world “moves backwards,” report warns

The New England Journal of Medicine • Correspondence: Clusters of Concern — Spatial Link between Childhood Undervaccination and Measles Outbreaks in South Carolina

The New England Journal of Medicine • Correspondence: Andes Hantavirus Outbreak on a Cruise Ship, 2026

JAMA • News: More Than 19 000 Measles Cases in a Month—What the Current Outbreak in Bangladesh Signals to the World

PLOS Neglected Tropical Diseases • Article: The cross-city mobility patterns and incubation period of the early-stage chikungunya fever outbreak in Guangdong Province, China, in 2025

 

Research and reporting

PLOS Neglected Tropical Diseases • Article: Strengthening frontline capacity for skin neglected tropical diseases: Findings from a global survey

PLOS Neglected Tropical Diseases • Article: Systematic review of health risk assessment in Africa’s bushmeat trade: Are there any risks assessed?

PLOS Neglected Tropical Diseases • Article: Effectiveness of community engagement in snakebite prevention and proper first aid practices: A community trial in rural Bangladesh

BMC Health Services Research • Article: Insights into collapse in ambulances (CIA): a retrospective analysis of interfacility transfers from Emergency Medical Services (EMS) of Sindh, Pakistan

 

Sexual and reproductive health

The Lancet eBioMedicine • Article: Effect of menstrual cups on vaginal health, reproductive tract and urogenital infections: a systematic review and meta-analysis

BMJ Global Health • Article: Ensuring an enabling environment for abortion self-care: individuals’ experiences with self-managed abortion in India
 

Tuberculosis

The Lancet Regional Health Southeast Asia • Article: Targeted next-generation sequencing for direct drug-resistant tuberculosis detection in sputum samples in Indonesia: an implementation study (2024–25)

The Lancet Regional Health Africa • Article: Treatment outcomes and post-treatment mortality among people with multidrug/rifampicin-resistant tuberculosis in Sierra Leone: a national cohort study

PLOS Medicine • Article: Differences in tuberculosis prevalence by sex in low- and middle-income countries over 1993–2025: A systematic review and meta-analysis

Tropical Medicine & International Health • Article: Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co-Infected With HIV

Tropical Medicine & International Health • Article: Epidemiological, Spatial and Predictive Analysis of Tuberculosis-Related Mortality in the Department of Risaralda (Colombia), 2020–2024

 

Vaccines

The Lancet eBioMedicine • Article: Estimated efficacy of the adjuvanted RSVPreF3 vaccine against diverse and worldwide predominant RSV strains, irrespective of RSV F protein variation: results of a post-hoc analysis from the AReSVi-006 trial

The New England Journal of Medicine • Practice: Childhood Vaccine Hesitancy

PLOS Neglected Tropical Diseases • Article: The need for balanced dengue vaccine protection: Insights from Thai surveillance data on four serotypes

PLOS Neglected Tropical Diseases • Article: Local heterogeneity in Lassa fever serology in rural Nigeria: Implications for vaccine trial site selection

PLOS Neglected Tropical Diseases • Article: Dengue vaccine acceptability in Peru: A mixed-methods study in two dengue-endemic Peruvian cities