Global health review
A weekly round-up of all the latest global health research from MSF projects and beyond
15 January 2020
This week, MSF authors an article in The Lancet assessing the immunogenicity and safety of one-fifth fractional doses of WHO pre-qualified yellow fever vaccines in Mbarara, Uganda, and Kilifi, Kenya. Fractional dosage of vaccines was safe and non-inferior compared to standard dosing, adding support to WHO policy on the use of fractional dosing of yellow fever vaccines for outbreak response.
In PLOS Medicine, MSF authors an article evaluating a multidisciplinary primary-level non-communicable disease programme in Irbid, Jordan, aimed at Syrian refugees and vulnerable Jordanians. Using routine clinic data to examine levels of blood pressure and diabetes control, the authors showed that the programme resulted in good treatment outcomes and reduced rates of treatment interruption.
In PLOS ONE, an article presents the first stage of a participatory, bottom-up approach in Kuc, Uganda, in which community members were involved in setting a research agenda to improve health in their community. A qualitative study in BMJ Global Health explores the ethical issues around Health and Demographic Surveillance Systems (HDSS) in sub-Saharan Africa, highlighting the need for specific ethics guidance for HDSS.
An MSF-authored article in Infectious Agents and Cancer assesses the feasibility, safety and outcomes of treating AIDS-associated Kaposi’s sarcoma with pegylated liposomal doxorubicin (PLD) in Maputo, Mozambique. PLD was safe, well-tolerated and effective as first-line chemotherapy for Kaposi’s sarcoma, and resulted in rapid improvements in quality of life.
Reminder: a virtual global launch of The Lancet Series on Women’s and Children’s Health in Conflict Settings will take place on January 25, and will involve discussions from a panel of experts and frontline workers on advancing health sector interventions for women and children in conflict settings.
Freja Nielsen, Austin Heuer, Jodie Pearlman and Holly Baker with MSF-authored article assistance from Patricia Kahn and Amelia Zhao
BMJ Global Health • Comment : Using treatment guidelines to improve antibiotic use: insights from an antibiotic point prevalence survey in Kenya
Climate change and planetary health
The Lancet Planetary Health • Comment : Planetary health diplomacy: a call to action
The Lancet Planetary Health • Correspondence : Equipping global health trainees for the climate crisis
Conflict, migration and health
Conflict and Health • Article : A case analysis of partnered research on palliative care for refugees in Jordan and Rwanda
Open Forum Infectious Diseases • Other ***MSF AUTHOR***: Immunogenicity of rVSVΔG-ZEBOV-GP Ebola Vaccine (ERVEBO™) in Participants by Age, Sex, and Baseline GP-ELISA Titer: A Post Hoc Analysis of Three Phase 2/3 Trials
JAMA • Article : Characterization of Ebola Virus–Associated Eye Disease
BMC Infectious Agents and Cancer • Article ***MSF AUTHOR***: Outcomes of AIDS-associated Kaposi sarcoma in Mozambique after treatment with pegylated liposomal doxorubicin
Tropical Medicine & International Health • Article : Predictors of glucose metabolism and blood pressure among Ethiopian individuals with HIV/AIDS after one‐year antiretroviral therapy
Open Forum Infectious Diseases • Article ***MSF AUTHOR***: Concomitant treatment of chronic hepatitis C with direct acting antivirals and multidrug-resistant tuberculosis is effective and safe
Malaria Journal • Article : Malaria micro-stratification using routine surveillance data in Western Kenya
Maternal and child health
BMC Pregnancy & Childbirth • Article ***MSF AUTHOR***: Resilience to maintain quality of intrapartum care in war torn Yemen: a retrospective pre-post study evaluating effects of changing birth volumes in a congested frontline hospital
The Lancet Global Health • Comment : A road to optimising maternal and newborn quality care measurement for all
The Lancet Global Health • Correspondence : COVID-19's lost generation of unvaccinated children and comment COVID-19's lost generation of unvaccinated children – Authors' reply
JAMA Pediatrics • Editorial : Intrapartum Maternal Oxygen Supplementation—Friend or Foe?
PLOS ONE • Article : Racial and geographic variation in effects of maternal education and neighborhood-level measures of socioeconomic status on gestational age at birth: Findings from the ECHO cohorts
Tropical Medicine & International Health • Article : Febrile seizures in an urban Tanzanian population: lessons learned from a community‐based random cluster survey
Neglected tropical diseases
The Lancet EClinical Medicine • Article : Global, regional, and national dengue burden from 1990 to 2017: A systematic analysis based on the global burden of disease study 2017
BugBitten • Blog : Deworming achieves progress towards 2030 NTD goals sub-Saharan Africa
PLOS NTDs • Viewpoint : Scabies-infested pregnant women: A critical therapeutic challenge
Tropical Medicine & International Health • Article : β‐cell dysfunction and insulin resistance in relation to prediabetes and diabetes among adults in north‐western Tanzania: a cross‐sectional study
The Lancet • Article : 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study and comment Long-term follow-up of recovered patients with COVID-19
The Lancet • World Report : Health systems neglected by COVID-19 donors
The Lancet • World Report : Polio in Afghanistan: a changing landscape
The Lancet Respiratory Medicine • Article : Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study and comment Sedation in mechanically ventilated patients with COVID-19
The Lancet Planetary Health • Editorial : A Pandemic Era
BMJ Global Health • Comment : What are SARS-CoV-2 genomes from the WHO Africa region member states telling us?
BMJ Global Health • Analysis : The global impact of the COVID-19 pandemic on the prevention, diagnosis and treatment of hepatitis B virus (HBV) infection
BMJ Global Health • Article : Boundaries of solidarity: a meta-ethnography of mask use during past epidemics to inform SARS-CoV-2 suppression
NEJM • Article : Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
JAMA • Perspectives : Sorting Out Whether Vitamin D Deficiency Raises COVID-19 Risk
JAMA • Article : SARS-CoV-2 Transmission From People Without COVID-19 Symptoms
JAMA • Viewpoint : Genetic Variants of SARS-CoV-2—What Do They Mean?
PLOS ONE • Article : The association of chest radiographic findings and severity scoring with clinical outcomes in patients with COVID-19 presenting to the emergency department of a tertiary care hospital in Pakistan
Transactions RSTMH • Article : Epidemiology and challenges of dengue surveillance in the WHO South-East Asia Region
Transactions RSTMH • Article : Use of modelling to modify trachoma elimination strategies affected by the COVID-19 pandemic
Research and reporting
BMJ Global Health • Article : State of the evidence: a survey of global disparities in clinical trials
Sexual and reproductive health
PLOS NTDs • Article : Congenital syphilis in Argentina: Experience in a pediatric hospital
Tropical Medicine & International Health • Article ***MSF AUTHOR***: Accuracy of molecular drug susceptibility testing amongst tuberculosis patients in Karakalpakstan, Uzbekistan
The Lancet EClinical Medicine • Article : Cost-effectiveness of scaling up short course preventive therapy for tuberculosis among children across 12 countries
The Lancet • Article ***MSF AUTHOR***: Immunogenicity and safety of fractional doses of yellow fever vaccines: a randomised, double-blind, non-inferiority trial and comment Public health role for fractional dosage of yellow fever vaccine
NEJM • Correspondence : Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination
WHO Bulletin • Editorial : Ensuring equitable access to vaccines for refugees and migrants during the COVID-19 pandemic
BMJ Opinion • Blog : Human challenge trials of covid-19 vaccines still have much to teach us
PLOS ONE • Article : Cohort profile: Study on Zika virus infection in Brazil (ZIKABRA study)